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Psychedelics exhibit similar Gq and β-arrestin2 activity at 5-HT2ARTo investigate the 5-HT2AR signaling profiles of classical psychedelics, we used bioluminescence resonance energy transfer approaches (BRET, Fig. 1A, B, Supplementary Table 1), which provide a proximity measure of intracellular transducer engagement. BRET is used extensively to quantify GPCR-biased agonism and has the advantage of not being susceptible to…
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